Title:
PRODUCTION OF SURFACE ANTIGEN OF HEPATITIS B VIRUS
Document Type and Number:
Japanese Patent JPH0690781
Kind Code:
A
Abstract:
PURPOSE: To obtain a surface antigen of hepatitis B virus useful as a vaccine.
CONSTITUTION: A transformant containing a DNA having a base sequence encoding surface antigen P31 of hepatitis B virus is cultured, the surface antigen P31 of hepatitis B virus is formed and accumulated in the culture mixture. The prepared P31-containing solution is purified by a purifying process including affinity chromatography treatment using poly-human serum albumin as a ligand to produce surface antigen P31 protein of hepatitis B virus. The surface antigen P31 protein of hepatitis B virus is useful as a vaccine for diagnosing, preventing and treating hepatitis B virus.
Inventors:
KIKUCHI MASAKAZU
FUJISAWA YUKIO
IKEYAMA SHUICHI
NISHIMURA TADASHI
FUJISAWA YUKIO
IKEYAMA SHUICHI
NISHIMURA TADASHI
Application Number:
JP11335493A
Publication Date:
April 05, 1994
Filing Date:
May 14, 1993
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K39/29; A61P31/12; C07H21/04; C07K1/16; C07K1/20; C07K1/22; C07K14/00; C07K14/02; C07K14/10; C07K14/18; C07K14/76; C12N1/00; C12N1/21; C12N15/00; C12N15/09; C12N15/51; C12N15/78; C12N15/81; C12P21/02; A61K38/00; C12R1/19; C12R1/865; (IPC1-7): C12P21/02; A61K39/29; C07K3/20; C07K15/14; C12N1/21; C12N15/51
Domestic Patent References:
| JPS5974985A | 1984-04-27 | |||
| JPS55104887A | 1980-08-11 |
Attorney, Agent or Firm:
Yasuo Asai (5 outside)
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