To simply produce the subject compound useful as a production intermediate for anilide derivatives having antagonistic actions on monocyte chemoattractant protein-1 (MCP-1) receptors, antagonistic actions, or the like, on CCR5 at a low cost by reacting tetrahydropyran-4-one with an amine under catalytic reducing conditions.
A compound represented by formula I is reacted with a compound represented by the formula: R1R2NH [R1 and R2 are each H or a (substituted)hydrocarbon group] (dimethylamine) under catalytic reducing conditions to thereby produce the objective compound represented by formula II (e.g. N,N-dimethyl-N-tetrahydropyran-4-ylamine). For example, the above reaction is carried out at -30 to +200°C, preferably about 0-100°C under usually about 0-100 atm, preferably about 0-10 atm, usually for about 0.1-24 h, preferably about 1-10 h by using a Pd-C catalyst and a reactional solvent such as tetrahydrofuran, methanol or ethanol.
IKEMOTO TOMOKI
TOMIMATSU KIMINORI
