Title:
体重を減少させる方法としてのCPT-1の促進
Document Type and Number:
Japanese Patent JP2005523270
Kind Code:
A
Abstract:
This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.
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Inventors:
Spali, Jagan N
Laundry, Leslie E
Gabriel, Ronnet
Francis Pea, Kuha Juda
Laundry, Leslie E
Gabriel, Ronnet
Francis Pea, Kuha Juda
Application Number:
JP2003565467A
Publication Date:
August 04, 2005
Filing Date:
February 10, 2003
Export Citation:
Assignee:
Jones Hopkins University School of Medicine
International Classes:
G01N33/50; A61K31/00; A61K31/195; A61K31/198; A61K31/205; A61K31/34; A61K31/365; A61K31/381; A61K45/00; A61P3/04; A61P43/00; C12Q1/48; G01N33/15; (IPC1-7): A61K45/00; A61K31/205; A61P3/04; A61P43/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa