Title:
PROSTACYCLINE ANALOQUE
Document Type and Number:
Japanese Patent JPS61129146
Kind Code:
A
Abstract:
Prostaglandin analogues of the formula: II (wherein R1 represents a hydrogen atom or an aliphatic or alicyclic hydrocarbon radical, Y1 represents a carbonyl or hydroxymethylene group, A1 represents an alkylene linkage containing 1, 2 or 3 carbon atoms and optionally bearing a methyl or ethyl substituent, R2 represents a hydrogen atom or a methyl or ethyl group and R3 represents a hydrogen atom or R2 and R3 form an alkylene linkage containing 2 or 3 carbon atoms, optionally bearing a methyl or ethyl substituent, such that the symbols A1, R2 and R3, together with the carbon atoms through which they are connected, may form a cycloalkyl ring of 5, 6, 7 or 8 carbon atoms, optionally bearing one or two methyl or ethyl substituents, or A1 and R3, together with the carbon atom through which they are connected, may form a phenylene ring optionally substituted by a halogen atom or by a trifluoromethyl group or by a straight- or branched-chain alkyl or alkoxy group containing from 1 to 6 carbon atoms, A2 represents a direct bond or a methylene group optionally bearing one or two methyl or ethyl substituents, X1 represents an ethylene, transvinylene or ethynylene group, Y2 represents a carbonyl or hydroxymethylene group, and either (i) A3 represents a straight- or branched-alkylene chain containing from 1 to 5 carbon atoms, Z1 represents a direct bond or an oxygen or sulphur atom, and R4 represents a group R4' which is an aliphatic or alicyclic hydrocarbon radical, or R4 represents a phenyl group optionally substituted by a halogen atom or by a trifluoromethyl group or by a straight- or branched-chain alkyl or alkoxy group containing from 1 to 6 carbon atoms, or (ii) A3 and Z1 both represent direct bonds and R4 represents a group R4' as hereinbefore defined) and cyclodextrin clathrates thereof and non-toxic salts thereof possess useful pharmacological properties.
Inventors:
TERANSU UIRIAMU HAATO
Application Number:
JP26161385A
Publication Date:
June 17, 1986
Filing Date:
November 22, 1985
Export Citation:
Assignee:
MAY & BAKER LTD
International Classes:
A61K31/557; A61P1/04; A61P7/02; A61P9/10; A61P9/12; A61P25/00; C07C51/00; C07C59/56; C07C59/62; C07C59/80; C07C67/00; C07C69/732; C07C69/734; C07C69/738; C07C313/00; C07C59/46; C07C323/55; C07C405/00; (IPC1-7): A61K31/557; C07C59/46; C07C59/54; C07C59/56; C07C59/62; C07C59/72; C07C59/80; C07C59/86; C07C59/88; C07C69/732; C07C69/734; C07C69/738; C07C149/26; C07C149/273
Attorney, Agent or Firm:
Chika Takagi
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