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Patent Searching and Data


Title:
PROSTAGLANDIN A1 ANALOGUE
Document Type and Number:
Japanese Patent JPH1143461
Kind Code:
A
Abstract:

To obtain the subject new compound having osteogenesis promoting activity.

This new compound is shown by formula I [R1 is a halogen, etc.; R2 is a group of the formula (CH2)qY2rR5 (Y2 is O, etc.; R5 is H, etc.; (r) is 0 or 1; (q) is 0-5); X is H, etc.; Z is ethylene, etc.], e.g. 6,7-dinol-5,8-inter- o-phenylene-PGA1. The compound of formula I is obtained by the following process: furan is lithiated and then reacted with a compound of formula II (R6 is a halogen, etc.), to form a compound, which is then rearranged, isomerized in the presence of an acid or base catalyst, and subjected to OH group protecting to form a compound of formula III (R7 is an OH-protecting group), which, in turn, is reacted with an organic borane compound corresponding to R1 in the presence of a base and a Pd catalyst to form a compound, which is then reacted with a compound prepared by reaction of an organolithium reagent with e.g. copper iodide, and the hydroxyl group of the resulting compound of formula IV (X2 is H, etc.), is deprotected, followed by conducting a dehydration.


Inventors:
TANAMI TOORU
SHIMAZAKI YOICHI
ONO NAOYA
Application Number:
JP20184397A
Publication Date:
February 16, 1999
Filing Date:
July 28, 1997
Export Citation:
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Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
A61K31/5575; A61P43/00; C07C49/753; C07C59/86; C07C59/90; C07C65/38; C07C65/40; C07C69/738; C07C323/22; C07C323/52; C07C405/00; A61K31/557; (IPC1-7): C07C49/753; A61K31/557; C07C59/86; C07C59/90; C07C65/38; C07C65/40; C07C69/738; C07C323/22; C07C323/52
Attorney, Agent or Firm:
Kitagawa Fuzo