Title:
プロスタグランジン誘導体
Document Type and Number:
Japanese Patent JP4563636
Kind Code:
B2
Abstract:
A prostaglandin derivative represented by the formula: wherein X is a halogen atom in the alpha - or beta -position, Y is an ethylene group, a vinylene group or an ethynylene group, A is a group represented by the formula: O(CH2)n, S(O)p(CH2)n, O(CH2)qO(CH2)r, O(CH2)qS(O)p(CH2)r, S(O)p(CH2)qS(O)p(CH2)r or S(O)p(CH2)qO(CH2)r (wherein n is an integer of 1 to 5, p is 0, 1 or 2, q is an integer of 1 to 3, and r is 0 or 1), R<1> is a C3-10 cycloalkyl group, a C1-4 alkyl-C3-10 cycloalkyl group, a C3-10 cycloalkyl-C1-4 alkyl group, a C5-10 alkyl group, a C5-10 alkenyl group, a C5-10 alkynyl group or a bridged cyclic hydrocarbon group, R<2> is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, and m is 0, 1 or 2Ü, a pharmaceutically acceptable salt thereof or a hydrate thereof. The present invention is to provide novel PG derivatives having an excellent PGD2-like agonistic activity and a sleep-inducing action.
Inventors:
Fumie Sato
Toru Tanami
Hideo Tanaka
Naoya Ono
Shin Yagi
Hitomi Hirano
Toru Tanami
Hideo Tanaka
Naoya Ono
Shin Yagi
Hitomi Hirano
Application Number:
JP2001523370A
Publication Date:
October 13, 2010
Filing Date:
September 08, 2000
Export Citation:
Assignee:
Taisho Pharmaceutical Co., Ltd.
Fumie Sato
Fumie Sato
International Classes:
C07C405/00; A61K31/5575; A61P9/10; A61P25/20; A61P27/06; A61P43/00
Domestic Patent References:
| JPH09501943A | 1997-02-25 | |||
| JPH07285929A | 1995-10-31 | |||
| JPH07233144A | 1995-09-05 | |||
| JPH06192218A | 1994-07-12 | |||
| JP2002520368A | 2002-07-09 | |||
| JPH02502009A | 1990-07-05 | |||
| JPH05503713A | 1993-06-17 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi