To obtain a new prostaglandin derivative having a strong intraocular pressure lowering activity, and useful for treating various diseases or symptoms attributable to the increase of intraocular pressure including glaucoma.
A prostaglandin derivative of formula I (X is a halogen; R1 is H or a 1-6C alkyl; R2 is a 3-10C cycloalkyl, a 4-11C cycloalkylmethyl or a 5-12C cycloalkylethyl; A is ethylene or vinylene) or its pharmaceutically permissible salt, e.g. 3-thia-9-deoxy-9-β-chloro-13,14-dihydro-16,17,18,19,20-pentanol-15- cyclohexyl-PGF2 methyl ester. A compound of formula I is obtained e.g. by reacting a compound of formula II (TBS is t-butyldimethylcyclohexyl; Et is ethyl) with a compound of formula III, reacting the obtained product with a compound of formula IV (EE is ethoxyethyl) and subjecting the resultant product to various treatments.
AMANO TAKEHIRO
KAMEO KAZUYA
TANAMI TOORU
MUTO MASARU
ONO NAOYA
GOTOU JIYUN
SATO FUMIE
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