Title:
PROSTAGLANDIN E1 ANALOG
Document Type and Number:
Japanese Patent JP3865843
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject new compound having slighter adverse effects than existing prostaglandin E1 analog and strong antiulcer action excellent in durability.
SOLUTION: This compound is shown by formula I {R is H or a 1-4C alkyl; R1 is a group of formula II (R2 is a 1-4C alkyl, a 3-8C alkyl or benzyl) or formula III [one of R3 and R4 is a hydroxyl group and the other is H or methyl; one of R5 and R6 is H or methyl and the other is OR7 (R7 is a 1-4C alkyl, a 3-8C cycloalkyl, benzyl or phenyl)]. The compound of formula I is obtained, for example, by reacting a compound of formula IV (TBS is t-butyldimethylsilyl; R8 is a group in which the hydroxyl of R1 is protected with TBS or a trimethylsilyl group) obtainable by a known method with a compound of formula V and deprotecting the protecting group of the hydroxyl group of the prepared compound by a conventional method.
Inventors:
Fumie Sato
Kazuya Kameo
Toru Tanami
Hideo Tanaka
Youichi Shimazaki
Naoya Ono
Kazuya Kameo
Toru Tanami
Hideo Tanaka
Youichi Shimazaki
Naoya Ono
Application Number:
JP33619796A
Publication Date:
January 10, 2007
Filing Date:
December 17, 1996
Export Citation:
Assignee:
Taisho Pharmaceutical Co., Ltd.
Fumie Sato
Fumie Sato
International Classes:
A61K31/557; C07C405/00; A61K31/5575; A61P1/04; (IPC1-7): C07C405/00; //A61K31/557
Domestic Patent References:
| JP7025847A | ||||
| JP7233145A | ||||
| JP7285930A |
Attorney, Agent or Firm:
Tomizo Kitagawa