To obtain the subject compound having weak hypotensive effect in spite of having strong and continuous blood flow increasing action and useful for treatment, etc., of peripheral circulatory disorder by esterifying a carboxylic acid at 1 position of prostaglandin E1 with a specific alcohol.
This compound is represented by formula I (R1 is a 4-12C alkyl), specifically prostaglandin E1-1,3-bis(hexanoyloxy)-2-propylester or prostaglandin E1-1,3-bis(dodecanoyloxy)-2-propylester. Furthermore, the compound is preferably obtained by heating, e.g. a compound of formula II (R2 is a protective group capable of eliminating under acidic conditions, e.g. tetrahydropyran-2-yl) in a mixed solution of acetic acid with water and tetrahydrofuran at 40-50°C to carry out elimination reaction of R2.
SEKO TAKUYA
MATSUMOTO RYOJI
HAMANO SHINICHI
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