Title:
PROSTAGLANDIN REDUCTASE
Document Type and Number:
Japanese Patent JP2005348733
Kind Code:
A
Abstract:
To provide a polypeptide effective for controlling lipid and glucose metabolism by controlling PPAR (peroxisome proliferator activated receptor) activity and a medicinal composition containing the polypeptide.
The present invention provides an isolated polypeptide not reducing leukotriene B4, but reducing 15-ketoprostaglandin and having a specific sequence or its functional equivalent and a double stranded ribonucleic acid (dsRNA) for inhibiting expression of 15-ketoprostaglandin-13-reductase.
Inventors:
CHUANG LEE-MING
CHANG ZEE-FEN
CHOU WEN-LING
CHANG ZEE-FEN
CHOU WEN-LING
Application Number:
JP2005170722A
Publication Date:
December 22, 2005
Filing Date:
June 10, 2005
Export Citation:
Assignee:
UNIV NAT TAIWAN
International Classes:
A61K31/12; A61K31/352; A61K31/353; A61K31/37; A61K31/7105; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/28; A61P9/10; A61P9/12; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P43/00; A61K45/00; C07K16/40; C12N9/02; C12N9/04; C12N15/09; C12P21/08; (IPC1-7): C12N9/02; A61K31/7105; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/28; A61P9/10; A61P9/12; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07K16/40; C12N15/09; C12P21/08
Domestic Patent References:
| JP2002516062A | 2002-06-04 | |||
| JP2003502012A | 2003-01-21 | |||
| JP2002542263A | 2002-12-10 | |||
| JP2003514533A | 2003-04-22 | |||
| JP2002516062A | 2002-06-04 | |||
| JP2003502012A | 2003-01-21 | |||
| JP2002542263A | 2002-12-10 | |||
| JP2003514533A | 2003-04-22 |
Other References:
JPN6010043749, "”Ｍｕｓ ｍｕｓｃｕｌｕｓ ＲＩＫＥＮ ｃＤＮＡ Ｂ８３００２６Ｈ２４ ｇｅｎｅ， ｍＲＮＡ （ｃＤＮＡ ｃｌｏｎｅ ＭＧＣ：２９２７５ ＩＭＡＧＥ：５０６８４１９）， ｃｏｍｐｌｅｔｅ ｃｄｓ．”", ［ｏｎｌｉｎｅ］ ＮＣＢＩ Ｎｕｃｌｅｏｔｉｄｅ
JPN6010043752, Ｃｙｔｏｇｅｎｅｔ． Ｇｅｎｏｍｅ Ｒｅｓ．, 2003, １０３, ７９−８３
JPN6010043754, Ｐｒｏｔｅｉｎｓ．, 20040815, ５６（３）, ６２９−３３
JPN6010043756, Ｐｒｏｓｔａｇｌａｎｄｉｎｓ Ｏｔｈｅｒ Ｌｉｐｉｄ Ｍｅｄｉａｔ．, 2002, ６８−６９, ４８３−９３
JPN6010043758, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1996, ２７１（５）, ２８４４−５０
JPN6010043752, Ｃｙｔｏｇｅｎｅｔ． Ｇｅｎｏｍｅ Ｒｅｓ．, 2003, １０３, ７９−８３
JPN6010043754, Ｐｒｏｔｅｉｎｓ．, 20040815, ５６（３）, ６２９−３３
JPN6010043756, Ｐｒｏｓｔａｇｌａｎｄｉｎｓ Ｏｔｈｅｒ Ｌｉｐｉｄ Ｍｅｄｉａｔ．, 2002, ６８−６９, ４８３−９３
JPN6010043758, Ｊ． Ｂｉｏｌ． Ｃｈｅｍ．, 1996, ２７１（５）, ２８４４−５０
Attorney, Agent or Firm:
Mikio Hatta
Yasuo Nara
Katsuyuki Utani
Ken Fujita
Masanori
Toshihiro Hasegawa
Yasuo Nara
Katsuyuki Utani
Ken Fujita
Masanori
Toshihiro Hasegawa
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