Title:
PROTAIN LABEL AND MEDICINE RELEASE SYSTEM
Document Type and Number:
Japanese Patent JPS62120378
Kind Code:
A
Abstract:
A bridging molecule carrying a drug, or a label such as a fluorophore, which adds across disulfide bonds of molecules, particularly proteins, and methods of manufacturing and using the bridging molecules, are disclosed. The bridging molecule is reactive with sulfhydryl groups formed by the reduction of disulfide bonds of the protein. The functional groups of the bridging molecules are typically -SH groups.
Inventors:
BIBARII PATSUKAADO
MAIKURU EDEIDEIN
AKIRA KOMORIYA
MAIKURU EDEIDEIN
AKIRA KOMORIYA
Application Number:
JP27304786A
Publication Date:
June 01, 1987
Filing Date:
November 18, 1986
Export Citation:
Assignee:
UNIV JOHNS HOPKINS
International Classes:
G01N21/76; A61K9/00; A61K39/395; A61K45/00; A61K47/48; C07D311/82; C07K1/107; G01N33/53; G01N33/532; G01N33/533; G01N33/58; (IPC1-7): A61K9/00; A61K39/395; A61K45/00; A61K47/00; C07D311/82; G01N21/76; G01N33/53; G01N33/532; G01N33/58
Attorney, Agent or Firm:
Aoki Akira