Title:
プロテアーゼ耐性型VEGF-D、その製造方法および使用方法
Document Type and Number:
Japanese Patent JP2009508525
Kind Code:
A
Abstract:
The present invention provides modified VEGF-D polypeptide variants that are resistant to serine protease processing and methods of making and using the same, as well pharmaceutical compositions comprising the peptide or a polynucleotide encoding the same. The VEGF-D variants comprise a VEGF homology domain, and at least one of (1) a C-terminal propeptide that is not cleavable by a serine protease, and (2) an N-terminal propeptide that is not cleavable by a serine protease. The VEGF-D variants can be made using site-directed mutagenesis. The VEGF-D variants are useful for the treatment of diseases such as cardiovascular disease and primary and secondary lymphedema, and for the prevention of stenosis and restenosis of blood vessels.
Inventors:
Paabonen Cali
Stacker stephen
Aachen mark
Stacker stephen
Aachen mark
Application Number:
JP2008532309A
Publication Date:
March 05, 2009
Filing Date:
September 19, 2006
Export Citation:
Assignee:
Begenix limited
International Classes:
C12N15/09; A61F2/04; A61F2/06; A61K38/22; A61K48/00; A61L31/00; A61P9/00; A61P9/08; A61P9/10; A61P9/14; A61P43/00; C07K14/52; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Patent business corporation Yuko patent office