Title:
タンパク質のリガンド-指向性共有的修飾
Document Type and Number:
Japanese Patent JP2013516422
Kind Code:
A
Abstract:
The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
Inventors:
Russell Sea. Petter
Charles F. Jewell
Quang Holly
Alabind Prasad Medoikonda
Dequiang Niu
LIQUIN QUIAO
Jaswinder Singh
Zheng Dong Zhu
Charles F. Jewell
Quang Holly
Alabind Prasad Medoikonda
Dequiang Niu
LIQUIN QUIAO
Jaswinder Singh
Zheng Dong Zhu
Application Number:
JP2012547291A
Publication Date:
May 13, 2013
Filing Date:
December 30, 2010
Export Citation:
Assignee:
Avila Therapeutics, Incorporated
International Classes:
C07K5/08; A61K31/05; A61K31/12; A61K31/122; A61K31/137; A61K31/16; A61K31/18; A61K31/215; A61K31/235; A61K31/24; A61K31/265; A61K31/337; A61K31/341; A61K31/343; A61K31/352; A61K31/357; A61K31/365; A61K31/366; A61K31/37; A61K31/381; A61K31/397; A61K31/4015; A61K31/4178; A61K31/42; A61K31/443; A61K31/454; A61K31/47; A61K31/4709; A61K31/496; A61K31/505; A61K31/506; A61K31/519; A61K31/52; A61K31/53; A61K31/5377; A61K31/538; A61K31/5386; A61K38/00; A61P43/00; C07C39/42; C07C47/46; C07C49/573; C07C69/94; C07C205/06; C07C327/16; C07D205/08; C07D207/273; C07D217/04; C07D239/48; C07D261/04; C07D305/12; C07D307/33; C07D307/60; C07D307/77; C07D307/93; C07D311/14; C07D311/76; C07D333/32; C07D333/36; C07D333/38; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/04; C07D405/12; C07D405/14; C07D409/12; C07D417/14; C07D473/38; C07D487/04; C07D491/147; C07D493/04; C07D495/04; C07D498/08; C07D513/04; C07D519/00; C07K1/13; C12N9/99; G16B15/30
Domestic Patent References:
JP2007522116A | 2007-08-09 | |||
JP2006508997A | 2006-03-16 |
Foreign References:
WO2009051822A1 | 2009-04-23 | |||
US20060174816A1 | 2006-08-10 | |||
US20090306085A1 | 2009-12-10 | |||
US20090137588A1 | 2009-05-28 | |||
US20070020684A1 | 2007-01-25 |
Other References:
JPN6015011602; Hur et al.: Bioorganic & Medicial Chemistry Letters Vol.18, No.22, p.5916-5919(2008)
JPN6015011607; Yang et al.: J. Am. Chem. Soc. Vol.131, No.38, p.13709-13721(2009)
JPN6015011607; Yang et al.: J. Am. Chem. Soc. Vol.131, No.38, p.13709-13721(2009)
Attorney, Agent or Firm:
Toru Ishikawa