Title:
タンパク質−細胞コンジュゲート、その調製法および使用
Document Type and Number:
Japanese Patent JP6400687
Kind Code:
B2
Abstract:
The present invention pertains to immunology, biomedicine field, specifically relates to a method for prevention or treatment of one or more of diseases relevant to the protein in the protein-cell conjugate, malignant tumors, infectious diseases caused by pathogenic microorganisms and autoimmune diseases. The method includes a step of administering to a subject in such need a prophylactically or therapeutically effective amount of a protein-cell conjugate, the said protein-cell conjugate is a conjugate formed by covalently linking a protein and a cell to a linker, respectively; the cell has free sulfhydryl groups distributed on its surface, when the cell is not linked to the linker; the linker is derived from a bifunctional cross-linking agent, and the bifunctional cross-linking agent comprises both a group capable of reacting with an amino group and a group capable of reacting with a sulfhydryl group.
Inventors:
Shea, Chang Ching
Guo, Essien
Woo, Hai Tao
One, Suigui
Guo, Essien
Woo, Hai Tao
One, Suigui
Application Number:
JP2016518826A
Publication Date:
October 10, 2018
Filing Date:
May 29, 2014
Export Citation:
Assignee:
Cansbio (Beijing) Biotechnology Company Limited
International Classes:
C07K17/06; A61K35/17; A61K39/00; A61P31/00; A61P35/00; A61P37/02; C12N5/078
Foreign References:
| WO2010141566A1 | ||||
| US5328840 |
Other References:
J. Immunological Methods, 1984年,Vol.74,p.229-239
Biochimica et Biophysica Acta, 1991年,Vol.1062,p.39-45
PNAS, 2003年,Vol.100, No.7,p.4001-4005
Nature Med., 2010年,Vol.16, No.9,p.1035-1041
Biochimica et Biophysica Acta, 1991年,Vol.1062,p.39-45
PNAS, 2003年,Vol.100, No.7,p.4001-4005
Nature Med., 2010年,Vol.16, No.9,p.1035-1041
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya
Yuhisa Osawa
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya
Yuhisa Osawa