Title:
PROTEIN COMPRISING CONSERVED REGION OF NEISSERIA MENINGITIDIS SURFACE ANTIGEN NhhA
Document Type and Number:
Japanese Patent JP2014024849
Kind Code:
A
Abstract:
To provide novel proteins that constitute modified forms of a Neisseria meningitidis surface antigen, and to provide encoding nucleic acids.
The modified surface proteins are characterized by having deletions of non-conserved amino acids, and thereby being capable of eliciting cross-protective immune responses against Neisseria meningitidis. The invention extends to the use of the modified surface antigens in diagnostics, in therapeutic and prophylactic vaccines and in the design and/or screening of pharmaceutical products. The modified surface antigens are particularly useful in vaccines which effectively immunize against a broader spectrum of N. meningitidis strains than would be expected from a corresponding wild-type surface antigen.
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Inventors:
PEAK IAN RICHARD ANSELM
JENNINGS MICHAEL PAUL
JENNINGS MICHAEL PAUL
Application Number:
JP2013188798A
Publication Date:
February 06, 2014
Filing Date:
September 11, 2013
Export Citation:
Assignee:
UNIV QUEENSLAND
International Classes:
C07K14/22; C12N15/09; A61K31/7088; A61K35/76; A61K38/00; A61K39/095; A61K48/00; A61P31/04; C12N1/21; C12N15/31; A61K39/00; A61P37/04; C12R1/36
Domestic Patent References:
| JPH06503465A | 1994-04-21 |
Foreign References:
| WO1999058683A2 | 1999-11-18 | |||
| WO1999036544A2 | 1999-07-22 | |||
| WO1999031132A1 | 1999-06-24 | |||
| EP0273116A2 | 1988-07-06 |
Other References:
JPN6010052822; Ｇｅｎｅ （１９９９） ｖｏｌ．２３１， ｎｏ．１-２， ｐ．１０５-１１０
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Hironobu Onda
Atsushi Honda
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