Title:
タンパク質ヘテロ二量体およびその使用
Document Type and Number:
Japanese Patent JP2021532796
Kind Code:
A
Abstract:
IL12aと上記のIL12aに融合する第1因子を含有する第1ポリペプチド鎖、および、IL12bと上記のIL12bに融合する第2因子を含有する上記の第1ポリペプチド鎖と異なる第2ポリペプチド鎖を有し、ここで、上記の第1因子と上記の第2因子は、それぞれ独立してIL2、GMCSF、IL7、IL15、IL21およびFLT3Lからなる群から選ばれるタンパク質ヘテロ二量体およびその使用である。上記のタンパク質ヘテロ二量体は、腫瘍の治療に用いられる。【選択図】図２
Inventors:
Zhang Jin Yu
Application Number:
JP2021505757A
Publication Date:
December 02, 2021
Filing Date:
July 30, 2019
Export Citation:
Assignee:
Zhang Jin Yu
International Classes:
C12N15/62; A61K31/7105; A61K35/76; A61K38/16; A61K48/00; A61P35/00; C07K14/52; C07K14/54; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/19; C12N15/24; C12N15/63; C12P21/02
Domestic Patent References:
| JP2003507012A | 2003-02-25 |
Other References:
WEISS ET AL., EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 7, no. 11, JPN6023014679, 2007, pages 1705 - 1721, ISSN: 0005039252
ESCHE ET AL., EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 30, no. 9, JPN6023014681, 2000, pages 2565 - 2575, ISSN: 0005039253
SCHILBACH ET AL., ONCOIMMUNOLOGY, vol. 4, no. 7, JPN6023014677, 2015, pages 1014760, ISSN: 0005039254
TIAN ET AL., INTERNATIONAL JOURNAL OF GYNECOLOGIC CANCER, vol. 21, no. 9, JPN6023014676, 2011, pages 1672 - 1678, ISSN: 0005039255
ESCHE ET AL., EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 30, no. 9, JPN6023014681, 2000, pages 2565 - 2575, ISSN: 0005039253
SCHILBACH ET AL., ONCOIMMUNOLOGY, vol. 4, no. 7, JPN6023014677, 2015, pages 1014760, ISSN: 0005039254
TIAN ET AL., INTERNATIONAL JOURNAL OF GYNECOLOGIC CANCER, vol. 21, no. 9, JPN6023014676, 2011, pages 1672 - 1678, ISSN: 0005039255
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office
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