Title:
プロテインキナーゼＣ阻害剤およびその使用方法
Document Type and Number:
Japanese Patent JP6644765
Kind Code:
B2
Abstract:
PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
Inventors:
Lugio, michael yosel
Papillon, julian
Bizarre, Michael Scott
Papillon, julian
Bizarre, Michael Scott
Application Number:
JP2017506392A
Publication Date:
February 12, 2020
Filing Date:
August 05, 2015
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D401/14; A61K31/497; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61K31/5386; A61K45/00; A61P27/02; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D405/14; C07D413/14; C07D487/04; C07D491/08
Domestic Patent References:
| JP2010520228A | ||||
| JP2013512281A | ||||
| JP2012529512A | ||||
| JP2013231049A | ||||
| JP2014506917A |
Foreign References:
| WO2013175388A1 |
Other References:
REN, Ji-Xia et al.,Discovery of Novel Pim-1 Kinase Inhibitors by a Hierarchical Multistage Virtual Screening Approach Based on SVM Model, Pharmacophore, and Molecular Docking,Journal of Chemical Information and Modeling,2011年,51(6),pp. 1364-1375
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki