Title:
プロテインチロシンキナーゼアゴニスト抗体
Document Type and Number:
Japanese Patent JPH09511644
Kind Code:
A
Abstract:
Agonist antibody is disclosed which binds to the extracellular domain of receptor protein tyrosine kinase pTK, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibody is useful for activating its respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.
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Inventors:
ウッド，ウィリアム・アイ
ゲッデル，デイビッド
ツァイ，シャオ・ピン
ベネット，ブライアン・ディ
マシューズ・ウィリアム
リー，ジェイムズ・エム
ゲッデル，デイビッド
ツァイ，シャオ・ピン
ベネット，ブライアン・ディ
マシューズ・ウィリアム
リー，ジェイムズ・エム
Application Number:
JP52594495A
Publication Date:
November 25, 1997
Filing Date:
April 04, 1995
Export Citation:
Assignee:
ジェネンテク・インコーポレイテッド
International Classes:
C12N15/09; A61K39/395; A61P43/00; C07H21/04; C07K7/08; C07K14/71; C07K14/82; C07K16/18; C07K16/28; C07K16/40; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/02; C12N15/12; C12P21/02; C12P21/08; C12Q1/68; C12Q1/6876; G01N33/566; G01N33/573; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; C07H21/04; C07K7/08; C07K16/40; C07K19/00; C12N5/10; C12N15/02; C12P21/02; C12P21/08; G01N33/566; G01N33/573
Attorney, Agent or Firm:
青山 葆 （外１名）