Title:
PROTEIN TYROSINE KINASE INHIBITOR FOR SUPPRESSION OF PROLIFERATION PROCESS IN MAMMAL CELL, CONTAINING BENZYLIDENE-AND CINNAMYLIDENE-MALONIC NITRILE DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JPH10279477
Kind Code:
A
Abstract:
To obtain the subject medicine capable of specifically preventing cell growth in mammals by including a substituted benzylidene and a cinnamylidene-malonic acid derivative.
This medicine contains a compound represented by the formula (R1 and R2 are each CN, CONH2, COOH, etc.; R3 is H, CH3 or OH; R4 to R7 are each H, OH, a 1-5C alkyl, a 1-5C alkoxy, NH2, CHO, a halogen, NO2, COOH, etc.) or its salt as an active ingredient. The compound of the formula includes e.g. 3,5-dihydroxybenzylidene-malonic nitrile. The medicine can be prepared in oral, rectal or parenteral form. The daily dose of the medicine is 10 mg to 10 g/adult. The compound of the formula can readily be available and has relatively simple structure and has no adverse effect.
Inventors:
LEVITZKI ALEXANDER
GILON CHAIM
CHOREV MICHAEL
GAZIT AVIV
GILON CHAIM
CHOREV MICHAEL
GAZIT AVIV
Application Number:
JP4403498A
Publication Date:
October 20, 1998
Filing Date:
February 25, 1998
Export Citation:
Assignee:
YISSUM RES DEV CO
International Classes:
A61K31/165; A61K31/19; A61K31/275; A61K31/357; A61K31/36; A61P35/00; A61P43/00; C07C57/42; C12N9/99; C07C59/48; C07C59/64; C07C63/64; C07C229/44; C07C231/12; C07C233/11; C07C235/34; C07C237/20; C07C255/36; C07C255/37; C07C255/40; C07C255/41; C07C255/42; C07C255/53; C07C327/44; C07D317/60; C07D317/62; (IPC1-7): A61K31/275; A61K31/165; A61K31/19; A61K31/36; C07D317/60; C07D317/62
Attorney, Agent or Firm:
Asahina Sota