Title:
プテリジン誘導体、その製造方法、およびその使用法
Document Type and Number:
Japanese Patent JP2005519912
Kind Code:
A
Abstract:
Compounds of the general formula (I) and their acid addition salts are provided wherein: R<1 >signifies a piperazino, p-phenylenediamino, a 2,5-diazabicyclo-[2.2.1]-heptane, a 2,5-diazabicyclo-[2.2.2]-octane radical or a 3,8-diazabicyclo-[3.2.1]-octane radical, which in each case can be substituted with at least one substituent, R<2>, R<4>, which are in each case the same, signify a pyrrolidino, thiazolidino, oxazolidino or imidazolidino radical, which in each case can be substituted with at least one substituent, and R<3 >signifies an alkyl, alkoxy, alkylmercapto or an alkylamino radical, which in each case can be substituted with at least one substituent. These pteridine derivatives are suitable for the inhibition of phosphodiesterases and therefore for the prophylaxis and/or treatment of thrombo-embolic, neurodegenerative diseases, inflammatory diseases, asthmatic diseases as well as hemato-oncological diseases.
Inventors:
Eisenbrand Gerhard
Meltz Karl-Heinz
Meltz Karl-Heinz
Application Number:
JP2003562117A
Publication Date:
July 07, 2005
Filing Date:
January 23, 2003
Export Citation:
Assignee:
Faustus Forcesungssee. Translational Cancer Research GM Behr
International Classes:
A61K31/519; A61P7/02; A61P11/06; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D475/08; C07D475/00; (IPC1-7): C07D475/00; A61K31/519; A61P7/02; A61P11/06; A61P25/00; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JPS61140585A | 1986-06-27 | |||
| JPS6025991A | 1985-02-08 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi