PURPOSE: To purify bile acid useful as a solubilizer for gallstone industrially advantageously, by adding an aqueous solution of an alkalizing agent to a solution of unpurified bile acid in an organic solvent, stirring them, collecting an organic solvent layer, adding an alkali aqueous solution to the organic solvent layer, stirring them, bringing an acid into contact with an aqueous solution layer, precipitating it.
CONSTITUTION: Unpurified bile acid dissolved or suspended in an organic solvent (e.g., 2-ethylhexanol, etc.) capable of separating a layer from water, the solution is blended with an aqueous solution of an alkalizing agent (e.g., tetramethylammonium hydroxide, etc.) or a mixed solvent of the organic solvent capable of separating a layer from water and an alkali aqueous solution, they are stirred, and an organic solvent layer is collected. The organic solution is blended with an alkali aqueous solution, stirred, an aqueous solution layer is collected, the collected solution is brought into contact with an acid, and precipitated, to give purified bile acid.
OKAMURA AKIO
SUZUKI YOSHINORI
| JPS58113202A | 1983-07-06 |