Title:
PYRAZINE DERIVATIVE AND BLOOD PLATELET AGGLUTINATION INHIBITOR OR ANTI-INFLAMMATORY AGENT CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPH0374386
Kind Code:
A
Abstract:
NEW MATERIAL:A compound expressed by formula I [X is H, halogen, cyano, lower alkyl, (di)lower alkylamino or lower alkoxy; ring A is formula II or III].
EXAMPLE: 2,3-Bis(p-methoxyphenyl)pyrido[2,3-b]pyrazine expressed by formula IV.
USE: A blood platelet agglutination inhibitor and anti-inflammatory agent.
PREPARATION: A benzyl derivative expressed by formula V and a 1,2-diamine derivative expressed by formula VI are heated in an organic solvent, such as ethanol, to provide a compound expressed by formula VII, which, together with sulfur, is subsequently heated at 100-180°C.
Inventors:
YANOSHITA RYOHEI
OKAMOTO KAZUO
YOMO YOSHIYUKI
SUWABE YASUSHI
OTA AKIHIRO
OKAMOTO KAZUO
YOMO YOSHIYUKI
SUWABE YASUSHI
OTA AKIHIRO
Application Number:
JP21018689A
Publication Date:
March 28, 1991
Filing Date:
August 16, 1989
Export Citation:
Assignee:
TERUMO CORP
International Classes:
A61K31/495; A61P7/02; C07D471/04; A61P29/00; (IPC1-7): A61K31/495; C07D471/04
Attorney, Agent or Firm:
Chika Takagi (1 person outside)
Next Patent: SPIROPYRAN-BASED COMPOUND