Title:
PYRAZINE DERIVATIVE
Document Type and Number:
Japanese Patent JP2599665
Kind Code:
B2
Abstract:
PURPOSE: To provide a novel compound which is useful as a prophylactic and therapeutic agent for autoimmune diseases, arteriosclerosis, ischemic cerebropathy, hepatic failure or renal failure, because it has inhibitive activity against superoxide released by guinea pig macrophage stimulation.
CONSTITUTION: A compound of formula I [R is H, lower alkyl; R1 is OH, lower alkoxy, lower alkyl; R2 is -CONR4R5 group (R4, R5 are H, cycloalkyl, lower alkyl), phenyl-lower alkyl which may have substituents on the phenyl ring; R3 is lower alkyl, phenyl], for example, 3-i-butyl-5-methoxy-6-[N- (3- methoxybenzyl)]-carbamoyl-1,2-dihydropyrazin-2-one-4-oxide. The compound of formula I is obtained by subjecting a carboxylic acid of formula II and an amine of formula III to a usual amide bond formation reaction.
Inventors:
Hitoshi Tone
Seiji Sato
Hideaki Sato
Katsumi Tamura
Toshiki Miyazaki
Yoshimasa Nakano
Seiji Sato
Hideaki Sato
Katsumi Tamura
Toshiki Miyazaki
Yoshimasa Nakano
Application Number:
JP11054892A
Publication Date:
April 09, 1997
Filing Date:
April 30, 1992
Export Citation:
Assignee:
Otsuka Pharmaceutical Co., Ltd.
International Classes:
A61K31/495; A61P1/16; A61P9/00; A61P9/08; A61P9/10; A61P13/02; A61P15/00; A61P29/00; A61P37/00; C07D241/24; C07D401/12; C07D403/06; C07D403/12; C07D405/12; C07D409/12; C07D417/12; (IPC1-7): C07D241/24; C07D401/12; C07D403/12; C07D417/12
Other References:
HETEROCYCLES=1990
Attorney, Agent or Firm:
Eiji Saegusa (4 others)