Title:
ピラジン誘導体、それらの製造及びそれらを含有する薬剤
Document Type and Number:
Japanese Patent JP4443036
Kind Code:
B2
Abstract:
The invention concerns pyrazine derivatives of formula (1) in which a pharmaceutical composition comprising at least one compound of formula:in whichR represents a nitrogen atom, R1 and R3 each represent the same radical selected from the group consisting of -CO-NR5R6, -CO-N(CH(CH2OH)2)2, -CO-N(CH2OH)2, -CO-N(CH2-CH(CH2OH)2)2, -CO-N(CH2-(CHOH)n-CH2OH)2 in which n is equal to 0, 1, 2, 3 or 4, -CH2-O-R6, -NR5-CO-R6, -CH2-NR5R6, -CH2-N(CH2OH)2, -CH2-N(CH2-(CHOH)y-CH2OH)2 in which y is equal to 0, 1, 2, 3 or 4, -CH2-N(CH(CH2OH)2)2 and -CH2-N(CH2-CH(CH2OH)2)2 and R2 and R4 each represents a hydrogen atom,R5 represents a hydrogen atom or an alkyl radical,R6 represents a radical -CH2-(CHOH)m-CH2OH in which m is equal to 0, 1, 2, 3 or 4, -alk-O-alk-CH2OH, -alk-O-alk, -CH(CH2OH)2, -C(CH2OH)3, -C(CH3) (CH2OH)2, -CH2-CH(CH2OH)2 or -CH(CH2OH)-(CHOH)x-CH2OH in which x is equal to 1, 2, 3 or 4, alk represents an alkyl radical, the alkyl radicals containing, unless otherwise stated, 1 to 6 carbon atoms in a straight or branched chain, stereoisomers thereof and salts thereof with an inorganic or organic acid and their preparation.
Inventors:
Basilar, Giorgiyu
Curry, Jean-Christophe
Ebel, Michel
Firocyu, Bruno
Mignani, Cergy
Curry, Jean-Christophe
Ebel, Michel
Firocyu, Bruno
Mignani, Cergy
Application Number:
JP2000503069A
Publication Date:
March 31, 2010
Filing Date:
July 15, 1998
Export Citation:
Assignee:
Aventis Pharma S.A.
International Classes:
C07D241/24; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4418; A61K31/4965; A61P3/10; C07D213/30; C07D213/38; C07D213/75; C07D213/81; C07D213/82; C07D241/12
Domestic Patent References:
| JP63216873A | ||||
| JP4230264A | ||||
| JP5255261A | ||||
| JP38008143B1 |
Other References:
P.D.J. GROOTENHUIS,COMPLEXES OF MACROMOLECULAR POLYETHERS AND NEUTRAL GUEST MOLECULES: 以下備考,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,米国,1986年12月31日,V108 N4 1986年発行,P780-788,A SYSTEMATIC APPROACH TO THE COMPLEXATION OF WATER MOLECULES BY 2,6-PYRIDINIUM CROWN ETHERS
KUMAR S,SYNTHETIC IONOPHORES PART 14: EFFECT OF PYRIDINE AND THIOETHER LIGATING UNITS 以下備考,TETRAHEDRON,英国,1996年10月14日,V52 N42,P13483-13492,ON AGSELECTIVITY IN 18-MEMBERED DIAMIDE-DIESTER MACROCYCLES<1
BELL,T.W. et al,Host-guest complexation. 24. Synthesis of multiheteromacrocycles containing intramolecularly interacting units or new steric barriers,Journal of the American Chemical Society,1982年,Vol.104, No.19,p.5185-8
PICARD,C. et al,Synthesis of macrocyclic dilactones with the aid of organotin compounds. Application to sulfur macrocycles (sulfides, sulfoxides, disulfides). Selective complexation with calcium ion,Tetrahedron,1986年,Vol.42, No.13,p.3503-19
IZUMI,T. et al,Synthesis and cation-complexing ability of ferrocene- or ruthenocene-functionalized crown ethers possessing 2,6-pyridino moieties,Bulletin of the Chemical Society of Japan,1988年,Vol.61, No.10,p.3565-8
KUMAR,S. et al,Silver-selective pyridine-based diamide-diester 18-membered macrocycle - synthesis and inophore character,Bioorganic & Medicinal Chemistry Letters,1993年,Vol.3, No.2,p.363-4
KADY,I.O. et al,Metal-catalyzed intramolecular hydrolysis of phosphate esters,Tetrahedron Letters,1995年,Vol.36, No.23,p.4031-34
KUMAR,S. et al,Synthesis and Association Behavior of Pyridine Based 18-Membered Diamide-Diester-Thioether Macrocycles,Tetrahedron Letters,1996年,Vol.37, No.12,p.2071-2
KUMAR S,SYNTHETIC IONOPHORES PART 14: EFFECT OF PYRIDINE AND THIOETHER LIGATING UNITS 以下備考,TETRAHEDRON,英国,1996年10月14日,V52 N42,P13483-13492,ON AGSELECTIVITY IN 18-MEMBERED DIAMIDE-DIESTER MACROCYCLES<1
BELL,T.W. et al,Host-guest complexation. 24. Synthesis of multiheteromacrocycles containing intramolecularly interacting units or new steric barriers,Journal of the American Chemical Society,1982年,Vol.104, No.19,p.5185-8
PICARD,C. et al,Synthesis of macrocyclic dilactones with the aid of organotin compounds. Application to sulfur macrocycles (sulfides, sulfoxides, disulfides). Selective complexation with calcium ion,Tetrahedron,1986年,Vol.42, No.13,p.3503-19
IZUMI,T. et al,Synthesis and cation-complexing ability of ferrocene- or ruthenocene-functionalized crown ethers possessing 2,6-pyridino moieties,Bulletin of the Chemical Society of Japan,1988年,Vol.61, No.10,p.3565-8
KUMAR,S. et al,Silver-selective pyridine-based diamide-diester 18-membered macrocycle - synthesis and inophore character,Bioorganic & Medicinal Chemistry Letters,1993年,Vol.3, No.2,p.363-4
KADY,I.O. et al,Metal-catalyzed intramolecular hydrolysis of phosphate esters,Tetrahedron Letters,1995年,Vol.36, No.23,p.4031-34
KUMAR,S. et al,Synthesis and Association Behavior of Pyridine Based 18-Membered Diamide-Diester-Thioether Macrocycles,Tetrahedron Letters,1996年,Vol.37, No.12,p.2071-2
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
Heigo Odashima
Heigo Odashima
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