Title:
ピラジニルメチルラクタム誘導体
Document Type and Number:
Japanese Patent JP2008500381
Kind Code:
A
Abstract:
The present invention relates to novel pyrazinylmethyl-lactam derivatives, that are compounds of the formula I wherein R1 is a group of the formula G1 or G2 depicted below, wherein R1, R3, R6, R13 X, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective agonists, antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1B receptors. The compounds of the invention are useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated.
Inventors:
Christopher John Herar
Application Number:
JP2007517475A
Publication Date:
January 10, 2008
Filing Date:
May 09, 2005
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D403/06; A61K31/497; A61K31/5377; A61P1/00; A61P3/04; A61P9/06; A61P9/10; A61P9/12; A61P15/08; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; C07D401/06; C07D405/14; C07D407/14; C07D413/06; C07D413/14
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa