Title:
プロテインキナーゼインヒビターとして有用なピラゾール化合物
Document Type and Number:
Japanese Patent JP2004509115
Kind Code:
A
Abstract:
This invention describes novel triazole compounds of formula IX: wherein Z1 is nitrogen or CR9 and Z2 is nitrogen or CH, provided that at least one of Z1 and Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from -R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring; R1, R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.
Inventors:
Gorek, Julian M. C.
Charlier, Jean-Damien
Ronald Negtel
David, Bebington
Debise, robert
Li, bread
Charlier, Jean-Damien
Ronald Negtel
David, Bebington
Debise, robert
Li, bread
Application Number:
JP2002526858A
Publication Date:
March 25, 2004
Filing Date:
September 14, 2001
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/415; A61K31/437; A61K31/4709; A61K31/4725; A61K31/501; A61K31/5025; A61K31/506; A61K31/517; A61K31/519; A61K31/52; A61K31/53; A61K31/5377; A61K31/541; A61K31/55; A61K45/00; A61P1/16; A61P3/08; A61P3/10; A61P3/14; C07D403/12; A61P5/00; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P25/18; A61P25/28; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D239/26; C07D239/36; C07D239/70; C07D239/88; C07D401/12; C07D401/14; C07D403/14; C07D405/14; C07D407/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D473/16; C07D475/10; C07D487/04; C07D491/04; C07D491/044; C07D491/048; C07D491/052; C07D491/107; C07D491/113; C07D491/20; C07D493/04; C07D495/04; C07D498/04; C07D513/04; C07D521/00; (IPC1-7): C07D401/14; A61K31/501; A61K31/52; A61K31/53; A61K45/00; A61P3/08; A61P3/10; A61P25/18; A61P25/28; A61P35/00; A61P43/00; C07D403/12; C07D403/14; C07D409/14; C07D471/04; C07D473/16; C07D487/04; C07D491/113; C07D495/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita