Title:
代謝調節型グルタミン酸レセプターのモジュレーターとしてのピラゾール誘導体
Document Type and Number:
Japanese Patent JP2010533147
Kind Code:
A
Abstract:
The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am and Bn are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors-subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
Inventors:
Borea, Christel
Ceranyl, silvine
Ceranyl, silvine
Application Number:
JP2010515516A
Publication Date:
October 21, 2010
Filing Date:
July 10, 2008
Export Citation:
Assignee:
ADEX Pharma S.A.
International Classes:
C07D401/04; A61K31/427; A61K31/433; A61K31/4439; A61P1/00; A61P1/06; A61P1/12; A61P3/10; A61P25/00; A61P25/02; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P43/00; C07D417/04; C07D417/14
Domestic Patent References:
| JP2005508344A | 2005-03-31 | |||
| JP2009523769A | 2009-06-25 | |||
| JP2003525291A | 2003-08-26 | |||
| JP2004521901A | 2004-07-22 | |||
| JP2002508754A | 2002-03-19 | |||
| JP2007517825A | 2007-07-05 | |||
| JP2006501183A | 2006-01-12 | |||
| JP2005538958A | 2005-12-22 | |||
| JP2010522188A | 2010-07-01 | |||
| JP2010523568A | 2010-07-15 | |||
| JP2009543827A | 2009-12-10 | |||
| JP2010505859A | 2010-02-25 | |||
| JP2010526027A | 2010-07-29 | |||
| JP2010516788A | 2010-05-20 | |||
| JP2010521487A | 2010-06-24 | |||
| JP2010530420A | 2010-09-09 |
Foreign References:
| WO2006122011A2 | 2006-11-16 | |||
| WO2006002981A1 | 2006-01-12 | |||
| WO2006109817A1 | 2006-10-19 | |||
| WO2007039439A1 | 2007-04-12 | |||
| WO2007129195A2 | 2007-11-15 | |||
| WO2008150446A1 | 2008-12-11 | |||
| WO2006126718A1 | 2006-11-30 | |||
| WO2007071348A1 | 2007-06-28 | |||
| US2411951A | 1946-12-03 | |||
| WO2003049542A1 | 2003-06-19 | |||
| WO2007024843A2 | 2007-03-01 | |||
| WO2005103036A1 | 2005-11-03 | |||
| WO2004075852A2 | 2004-09-10 |
Other References:
JPN5010012320; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［ＯＮＬＩＮＥ］ , 20000211, ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ ＳＥＲＶＩＣＥ
JPN5010012321; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［ＯＮＬＩＮＥ］ , 20000211, ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ ＳＥＲＶＩＣＥ
JPN5010012322; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［ＯＮＬＩＮＥ］ , 20000211, ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ ＳＥＲＶＩＣＥ
JPN5010012323; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［ＯＮＬＩＮＥ］ , 20000211, ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ ＳＥＲＶＩＣＥ
JPN6013030143; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４７（２０）, 2004, ４８１８-４８２８
JPN6013030141; Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４０Ｂ（７）, 2001, ６３６-６３９
JPN5010012321; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［ＯＮＬＩＮＥ］ , 20000211, ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ ＳＥＲＶＩＣＥ
JPN5010012322; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［ＯＮＬＩＮＥ］ , 20000211, ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ ＳＥＲＶＩＣＥ
JPN5010012323; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［ＯＮＬＩＮＥ］ , 20000211, ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ ＳＥＲＶＩＣＥ
JPN6013030143; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４７（２０）, 2004, ４８１８-４８２８
JPN6013030141; Ｉｎｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ， Ｓｅｃｔｉｏｎ Ｂ： Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｉｎｃｌｕｄｉｎｇ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４０Ｂ（７）, 2001, ６３６-６３９
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe