NEW MATERIAL: A compd. expressed by formula I and its salt wherein A is C=O or C=S; B is O, NR4 or CR5R6 (R4 is H, alkyl, OH, alkoxy, aryloxy, etc.; R5 and R6 are R2); R1 is aromatic carbon cyclic group or aromatic heterocyclic group with any substituents as desired and having 1 to 3 condensed or non-condensed ring each comprising 5 to 7 atoms; R2 is H, NR8R9 (R8, R9 is H or alkyl), halogen, alkyl, OH, CN, etc.; Z is H, pharmaceutically acceptable salt or metabolically cleavable group.
EXAMPLE: 1-(3-chlorophenyl)-2H,4H-tetrahydro-1,2,4-triazin-3-one.
USE: Lipoxygenase inhibitor.
PREPARATION: For example, a R1-substd. hydrazine is allowed to react with a R2-substd. haloethyl isocyanate expressed by formula II (X is halogen) to obtain a compd. expressed by formula III, which is then cyclized in a polar aprotic solvent to obtain a compd. expressed by formula IV.
JIYOOJI DABURIYUU KAATAA
ANWAA BATSUSHIYA
BURUUSU PII GAN
RICHIYAADO DEII DAIYAA
PURAMIRA EI BAATEIA
