Title:
グルコキナーゼアクチベーターとして有用なピリジン誘導体
Document Type and Number:
Japanese Patent JP5567481
Kind Code:
B2
Abstract:
Novel heterocyclic compounds of the formula I in which R1, R2, R3, R4 and D have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
Inventors:
Burgdorf, Lars, Torre
Bayer, Norbert
Greys, Johannes
Sharon, Christine
Clavo, Daniel
Bayer, Norbert
Greys, Johannes
Sharon, Christine
Clavo, Daniel
Application Number:
JP2010528282A
Publication Date:
August 06, 2014
Filing Date:
August 13, 2008
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K31/4439; C07D417/12; A61K31/444; A61P3/04; A61P3/10; A61P13/12; A61P25/00; A61P43/00; C07D417/14
Domestic Patent References:
| JP2007504229A | ||||
| JP2004502692A | ||||
| JP60246371A | ||||
| JP63135383A | ||||
| JP2010527911A | ||||
| JP2010520887A | ||||
| JP2005518391A | ||||
| JP2005525291A |
Foreign References:
| WO2007089512A1 | ||||
| WO2005090332A1 | ||||
| US20050227989 | ||||
| WO2005040112A1 | ||||
| WO2006122011A1 | ||||
| WO2006118231A1 | ||||
| WO2007053345A1 | ||||
| WO2008091770A1 | ||||
| WO2007007041A1 | ||||
| WO2007051846A1 | ||||
| WO2004076420A1 |
Other References:
KAMENECKA,DIPYRIDYL AMINES: POTENT METABOTROPIC GLUTAMATE SUBTYPE 5 RECEPTOR ANTAGONISTS,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,PERGAMON, ELSEVIER SCIENCE,2005年10月 1日,V15 N19,P4350-4353
Misra R.N. et al,Bioorganic and Medicinal Chemistry Letters,2004年,Vol.14,pp.2973-2977
JONCKERS T H M,SELECTIVE PALLADIUM-CATALYZED AMINATIONS ON DICHLOROPYRIDINES,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS,2001年 8月 6日,V57 N32,P7027-7034
K.T.J. LOONES,ORTHOGONAL AND AUTO-TANDEM CATALYSIS,JOURNAL OF ORGANIC CHEMISTRY,2006年,V71 N1,P260-264
E.M. GOUGE,BIDENTATE CHELATE COMPOUNDS,INORGANIC CHEMISTRY,1978年,V17 N2,P270-275
K.W. ANDERSON,MONODENTATE PHOSPHINES PROVIDE HIGHLY ACTIVE CATALYSTS 以下備考,ANGEWANDTE CHEMIE,2006年,V118,P6673-6677,FOR PD-CATALYZED C-N BOND-FORMING REACTIONS OF HETEROAROMATIC HALIDES/AMINES AND (H)N-HETEROCYCLES
Misra R.N. et al,Bioorganic and Medicinal Chemistry Letters,2004年,Vol.14,pp.2973-2977
JONCKERS T H M,SELECTIVE PALLADIUM-CATALYZED AMINATIONS ON DICHLOROPYRIDINES,TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS,2001年 8月 6日,V57 N32,P7027-7034
K.T.J. LOONES,ORTHOGONAL AND AUTO-TANDEM CATALYSIS,JOURNAL OF ORGANIC CHEMISTRY,2006年,V71 N1,P260-264
E.M. GOUGE,BIDENTATE CHELATE COMPOUNDS,INORGANIC CHEMISTRY,1978年,V17 N2,P270-275
K.W. ANDERSON,MONODENTATE PHOSPHINES PROVIDE HIGHLY ACTIVE CATALYSTS 以下備考,ANGEWANDTE CHEMIE,2006年,V118,P6673-6677,FOR PD-CATALYZED C-N BOND-FORMING REACTIONS OF HETEROAROMATIC HALIDES/AMINES AND (H)N-HETEROCYCLES
Attorney, Agent or Firm:
Kiyoji Kuzuwa
Noriki Mitsuhashi
Noriki Mitsuhashi
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