Title:
ピリミジン‐２，４‐ジアミン誘導体及びそれを有効成分として含有する抗癌用医薬組成物
Document Type and Number:
Japanese Patent JP6622726
Kind Code:
B2
Abstract:
The present invention relates to a pyrimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for prevention or treatment of cancer comprising the same as an effective ingredient. A compound according to the present invention has the good effect of inhibiting anaplastic lymphoma kinase (ALK) activity, whereby a therapeutic effect on cancer cells having an anaplastic lymphoma kinase (ALK) fusion protein such as EML4-ALK, NPM-ALK, etc. can be enhanced and it is expected that a recurrence of cancer will be effectively inhibited. As such, the compound can be effectively used in a pharmaceutical composition for prevention or treatment of cancer.
Inventors:
Yun Chang Soo
Kim Hyun Le
Chosan Yun
Jun Hee Jun
Lee Kwan Ho
Cheecheon Haku
Lee Jung Ok
Park Chihoun
Kim Pirho
Huan John Aeon
Haja Do
Ansanju
Kim Hyun Le
Chosan Yun
Jun Hee Jun
Lee Kwan Ho
Cheecheon Haku
Lee Jung Ok
Park Chihoun
Kim Pirho
Huan John Aeon
Haja Do
Ansanju
Application Number:
JP2016573780A
Publication Date:
December 18, 2019
Filing Date:
May 21, 2015
Export Citation:
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
International Classes:
C07D401/12; A61K31/4985; A61K31/506; A61K31/55; A61P35/00; A61P43/00; C07D401/14; C07D403/12; C07D405/14; C07D471/04
Domestic Patent References:
| JP2011516555A | ||||
| JP2011523646A | ||||
| JP2014504646A | ||||
| JP2010507665A | ||||
| JP2010512329A |
Foreign References:
| WO2012125603A1 |
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Satoshi Morikawa
Hiroyuki Tomita