Title:
GSK-3阻害剤として有用なピリミジンベースの化合物
Document Type and Number:
Japanese Patent JP2005516005
Kind Code:
A
Abstract:
The present invention provides a compound of formula (I): (I), or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders, such as diabetes, cancer, stroke and Alzheimer's disease.
Inventors:
Deborah Chokette
Robert Jay Davis
Marion W. Wona Maker
Robert Jay Davis
Marion W. Wona Maker
Application Number:
JP2003550788A
Publication Date:
June 02, 2005
Filing Date:
December 09, 2002
Export Citation:
Assignee:
Vertex Pharmaceuticals, Inc.
International Classes:
A61K31/506; A61K31/517; A61K31/519; A61K45/00; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/14; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D239/94; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D417/12; C07D471/04; C07D475/10; C07D487/04; C07D495/04; (IPC1-7): C07D239/94; A61K31/506; A61K31/517; A61K31/519; A61K45/00; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/14; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07D401/12; C07D403/12; C07D409/14; C07D471/04
Attorney, Agent or Firm:
Motohiro Kurauchi
Hiroshi Kazama
Endo Azusa
Takumi Yoshida
Taku Nakajima
Hiroshi Kazama
Endo Azusa
Takumi Yoshida
Taku Nakajima