Title:
ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体
Document Type and Number:
Japanese Patent JP4694963
Kind Code:
B2
Abstract:
Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor (especially CXCR2) activity, and may be in the treatment (therapeutic or prophylactic) of conditions/diseases in human and non-human animals which are exacerbated or caused by excessive or unregulated production of chemokines.
Inventors:
Mark Richard Ebden
Premuji Megani
Antony Ronald Cook
John Steel
Lal Rushkar Shin Chima
Premuji Megani
Antony Ronald Cook
John Steel
Lal Rushkar Shin Chima
Application Number:
JP2005501216A
Publication Date:
June 08, 2011
Filing Date:
August 20, 2003
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D239/56; A61P9/10; A61P19/02; A61P19/10; A61P37/06; A61P37/08; C07D239/60; C07D401/04; C07D401/12; C07D403/12; C07D413/04; C07D413/12; C07D413/14; C07D417/12; A61K31/505; A61K45/00; A61P1/04; A61P3/10; A61P5/14; A61P7/04; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P15/08; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/14; A61P19/04; A61P21/04; A61P25/00; A61P25/06; A61P25/08; A61P25/14; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P43/00
Domestic Patent References:
| JP10509134A | ||||
| JP3197467A | ||||
| JP61118372A |
Foreign References:
| WO2000076980A1 |
Other References:
RODRIGUEZ, M.,NUCLEOSIDES & NUCLEOTIDES,1987年,V6 N5,P887-899
NOGIMORI, T.,JOURNAL OF MEDICINAL CHEMISTRY,1985年,V28 N11,P1692-1694
COBO, JUSTO,TETRAHEDRON,1994年,V50 N34,P10345-10358
HUEBSCH, WALTER,HELVETICA CHIMICA ACTA,1988年,V71 N6,P1379-1391
ZAMBELI,NEVENKA,ACTA PHARMACEUTICA JUGOSLAVICA,1971年,V21 N2,P91-95
NOGIMORI, T.,JOURNAL OF MEDICINAL CHEMISTRY,1985年,V28 N11,P1692-1694
COBO, JUSTO,TETRAHEDRON,1994年,V50 N34,P10345-10358
HUEBSCH, WALTER,HELVETICA CHIMICA ACTA,1988年,V71 N6,P1379-1391
ZAMBELI,NEVENKA,ACTA PHARMACEUTICA JUGOSLAVICA,1971年,V21 N2,P91-95
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai