Title:
ＰＧＥ２レセプター調節剤としてのピリミジン誘導体
Document Type and Number:
Japanese Patent JP7159215
Kind Code:
B2
Abstract:
The present invention relates to pyrimidine derivatives of formula (I)wherein (R1)n, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
Inventors:
Christoph Boss
Olivier Colminbowf
Heinz FLET'S
Isabel Riotier
David Pozzi
Silvia Richard-Buildstein
Elveginto
Thierry Schiffalen
Olivier Colminbowf
Heinz FLET'S
Isabel Riotier
David Pozzi
Silvia Richard-Buildstein
Elveginto
Thierry Schiffalen
Application Number:
JP2019563493A
Publication Date:
October 24, 2022
Filing Date:
May 17, 2018
Export Citation:
Assignee:
IDORSIA PHARMACEUTICALS LTD
International Classes:
C07D239/42; A61K31/505; A61K31/506; A61K45/00; A61P9/00; A61P9/10; A61P13/12; A61P15/00; A61P15/16; A61P25/00; A61P25/04; A61P35/00; A61P43/00; C07D403/04; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/14; C07D417/04; C07D417/14
Domestic Patent References:
| JP2015514804A | ||||
| JP2016533366A |
Foreign References:
| WO2008152093A1 |
Other References:
Cancer Discovery,2014年,Vol.4, No.10,pp.1126-1139
Attorney, Agent or Firm:
Michie Obuchi
Fuse Yukio
Fuse Yukio