Title:
オートタキシン阻害活性を有するピリミジノン誘導体
Document Type and Number:
Japanese Patent JP6632532
Kind Code:
B2
Abstract:
A. compound according to any one of formula (Ia) to (Ic) or (II), or its pha rmaceutically acceptable salt:
or
wherein R 1 , R 2 , R 3 , R 4a , R 4c , R 5 , R 15 , ring A, X 1 and X 2 are as defined in t he description.
Inventors:
Tetsuo Nagano
Takayoshi Okabe
Hiroshi Kojima
Kawaguchi Mitsuyasu
Nuriki
Ryuichiro Ishiya
Hiroshi Nishimasu
Jun Aoki
Nobuyuki Tanaka
Yasuhiko Kanda
Onioi Yoshiyuki
Yusuke Tateno
Shiro Kida
Junji Yamane
Toshihiro Wada
Takayoshi Okabe
Hiroshi Kojima
Kawaguchi Mitsuyasu
Nuriki
Ryuichiro Ishiya
Hiroshi Nishimasu
Jun Aoki
Nobuyuki Tanaka
Yasuhiko Kanda
Onioi Yoshiyuki
Yusuke Tateno
Shiro Kida
Junji Yamane
Toshihiro Wada
Application Number:
JP2016545655A
Publication Date:
January 22, 2020
Filing Date:
August 28, 2015
Export Citation:
Assignee:
National University Corporation Tokyo University
Tohoku University
Shionogi Pharmaceutical Co., Ltd.
Tohoku University
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D239/36; A61K31/505; A61K31/506; A61K31/5377; A61K31/541; A61K31/551; A61P9/10; A61P11/00; A61P13/02; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P19/02; A61P25/04; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D239/47; C07D239/52; C07D239/54; C07D239/56; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D405/06; C07D405/12; C07D405/14; C07D409/06; C07D409/12; C07D413/06; C07D413/10; C07D413/14; C07D417/06; C07D417/10; C07D417/12; C07D453/02; C07D471/10; C07D491/107; C07D498/08
Domestic Patent References:
| JP62270563A | ||||
| JP61044872A |
Foreign References:
| WO1993001198A1 | ||||
| WO2000029387A1 | ||||
| WO2001068613A1 | ||||
| WO2007146761A1 |
Other References:
Bioorganic & Medicinal Chemistry Letters,2009年,19,5346-5350
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry,1998年,18,3065-3080
Phosphorus, Sulfur and Silicon and the Related Elements,1996年,109-110,229-232
J. Org. Chem.,2011年,76,5309-5319
Tetrahedron,2013年,69,1387-1396
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry,1998年,18,3065-3080
Phosphorus, Sulfur and Silicon and the Related Elements,1996年,109-110,229-232
J. Org. Chem.,2011年,76,5309-5319
Tetrahedron,2013年,69,1387-1396
Attorney, Agent or Firm:
Samejima Mutsumi
Masahiro Nitta
Yasushi Ochiai
Masahiro Nitta
Yasushi Ochiai