Title:
PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS
Document Type and Number:
Japanese Patent JP2019001819
Kind Code:
A
Abstract:
To provide a TrkA kinase inhibitor useful in treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.SOLUTION: The invention provides pyrrolidinyl urea and pyrrolidinyl thiourea compounds represented by a formula I, where the Y-B moiety and the NH-C(=X)-NH moiety are in the trans configuration.SELECTED DRAWING: None
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Inventors:
ALLEN SHELLEY
STEVEN W ANDREWS
BLAKE JAMES F
KEVIN R CONDROSKI
JULIA HAAS
LILY HUANG
JIANG YUTONG
TIMOTHY KERCHER
GABRIELLE R KOLAKOWSKI
SEO JEONGBEOB
STEVEN W ANDREWS
BLAKE JAMES F
KEVIN R CONDROSKI
JULIA HAAS
LILY HUANG
JIANG YUTONG
TIMOTHY KERCHER
GABRIELLE R KOLAKOWSKI
SEO JEONGBEOB
Application Number:
JP2018172485A
Publication Date:
January 10, 2019
Filing Date:
September 14, 2018
Export Citation:
Assignee:
ARRAY BIOPHARMA INC
International Classes:
C07D401/14; A61K31/4155; A61K31/416; A61K31/4162; A61K31/4178; A61K31/4192; A61K31/4196; A61K31/422; A61K31/4245; A61K31/427; A61K31/433; A61K31/437; A61K31/4439; A61K31/444; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61P25/00; A61P29/00; A61P33/00; A61P35/00; A61P43/00; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D487/04; C07D491/048; C07D495/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita