Title:
Pyrrolo [2 and 1-f], and [1, 2, 4] triazine compound, its manufacturing method, and a use
Document Type and Number:
Japanese Patent JP6067107
Kind Code:
B2
Abstract:
The present invention relates to a pyrrolo[2,1- f ][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof, and a preparation method and application thereof. The pyrrolo[2,1- f ][1,2,4]triazine compound has a structure expressed in general formula (I). The pyrrolo[2,1- f ][1,2,4]triazine compound expressed in general formula (I) can inhibit a phosphatidylinositol-3 kinase (PI3K) signal pathway, thereby being used to prepare medicine for treating phosphatidylinositol-3 kinase related diseases such as cancer.
Inventors:
Yang, Chunhao
Men, Rinhwa
Chen, Yang Hong
One, Shan
Tan, Chun
Lee Jarpen
Din, Jean
Chen, Yi
Men, Rinhwa
Chen, Yang Hong
One, Shan
Tan, Chun
Lee Jarpen
Din, Jean
Chen, Yi
Application Number:
JP2015514329A
Publication Date:
January 25, 2017
Filing Date:
April 23, 2013
Export Citation:
Assignee:
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD
International Classes:
C07D487/04; A61K31/5377; A61P35/00; A61P43/00; C07D519/00
Domestic Patent References:
| JP2011500702A | ||||
| JP2010512338A | ||||
| JP2008516973A |
Foreign References:
| WO2011089400A1 | ||||
| WO2011141713A1 | ||||
| WO2010119264A1 | ||||
| WO2010002472A1 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa
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