Title:
神経原線維濃縮体のイメージング剤としてのピロロ［２，３−Ｃ］ピリジン
Document Type and Number:
Japanese Patent JP6513107
Kind Code:
B2
Abstract:
or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology. The invention further relates to a method of measuring clinical efficacy of therapeutic agents for Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.
Inventors:
Abbas M
Eric, Hostettler
Greshock, Thomas
Lee, Jin
Moore, Keith Pee
Benasef, Idris
Mulhan, james
Cernic, Harold
Wong, Yaodi
Yang, Kung
Fu Jiang Min
Eric, Hostettler
Greshock, Thomas
Lee, Jin
Moore, Keith Pee
Benasef, Idris
Mulhan, james
Cernic, Harold
Wong, Yaodi
Yang, Kung
Fu Jiang Min
Application Number:
JP2016572520A
Publication Date:
May 15, 2019
Filing Date:
June 09, 2015
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D471/04; A61K51/04; A61P25/28; C07D519/00
Domestic Patent References:
| JP2008516004A | ||||
| JP2011521959A |
Foreign References:
| CN103450152A | ||||
| WO2014140592A1 | ||||
| WO2013040183A1 | ||||
| WO2013181075A1 |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama