Title:
VEGF受容体型チロシンキナーゼの阻害薬としてのキナゾリン誘導体
Document Type and Number:
Japanese Patent JP2007501212
Kind Code:
A
Abstract:
The present invention relates to compounds of the Formula (I): wherein Z is -NH-, -O- or -S-; R1 represents bromo or chloro; R3 represents C1-3alkoxy or hydrogen; R2 is selected from one of the following three groups: (i) Q1X1- wherein X1 and Q1 are as defined herein; (ii) Q15W3- wherein Q15 and W3 are as defined herein; and (iii) Q21W4C1-5alkylX1 wherein X1, W4 and Q21 are as defined herein; and salts thereof; their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm blooded animals; processes for the preparation of such compounds; pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof and methods of treating disease states involving angiogenesis by administering a compound of formula (I) or a pharmaceutically acceptable salt thereof. The compounds of formula (I) inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.
Inventors:
Hennekin, Laurent Francois Andre
Application Number:
JP2006522409A
Publication Date:
January 25, 2007
Filing Date:
August 05, 2004
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D401/12; A61K31/517; A61K31/5377; A61P3/10; A61P9/00; A61P9/10; A61P13/12; A61P15/00; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D401/14; C07D491/04; C07D491/056
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura