PURPOSE: To obtain a new quinoline compound having inhibitory action on allergy and ulcer.
CONSTITUTION: A compound shown by the formula (R1 is hydroxyaryl; R2 is amidated carboxy) and a salt thereof such as N-(1H-tetrazol-5-yl)-1-(4- methoxyphenoxy)-4H-quinolizin-4-one-3-carboxamide. The compound shown by formula is obtained by reacting 2-chloromethylpyrimidine hydrochloride with 4-methoxyphenol and potassium carbonate in a solvent under heating to give 2-(4-methoxyphenoxymethyl) pyridin, then obtaining a yellow solid substance of 1-(4-methoxyphenoxy)-4H-quinolizin-4-one-3-carboxylic acid from 2-(4- methoxyphenoxymethyl)pyridine, suspending the yellow solid substance in a solvent, adding 1,1'-carbonyldiimidazole and further 5-amino-1H-tetrazole to the suspension to give the objective compound.
KURODA AKIO