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Patent Searching and Data


Title:
QUINOLIDINONE COMPOUND AND ITS SALT
Document Type and Number:
Japanese Patent JPH04257582
Kind Code:
A
Abstract:

PURPOSE: To obtain a new quinoline compound having inhibitory action on allergy and ulcer.

CONSTITUTION: A compound shown by the formula (R1 is hydroxyaryl; R2 is amidated carboxy) and a salt thereof such as N-(1H-tetrazol-5-yl)-1-(4- methoxyphenoxy)-4H-quinolizin-4-one-3-carboxamide. The compound shown by formula is obtained by reacting 2-chloromethylpyrimidine hydrochloride with 4-methoxyphenol and potassium carbonate in a solvent under heating to give 2-(4-methoxyphenoxymethyl) pyridin, then obtaining a yellow solid substance of 1-(4-methoxyphenoxy)-4H-quinolizin-4-one-3-carboxylic acid from 2-(4- methoxyphenoxymethyl)pyridine, suspending the yellow solid substance in a solvent, adding 1,1'-carbonyldiimidazole and further 5-amino-1H-tetrazole to the suspension to give the objective compound.


Inventors:
OKU TERUO
KURODA AKIO
Application Number:
JP10525891A
Publication Date:
September 11, 1992
Filing Date:
February 12, 1991
Export Citation:
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Assignee:
FUJISAWA PHARMACEUTICAL CO
International Classes:
A61K31/435; A61P1/04; A61P37/08; C07D455/02; (IPC1-7): A61K31/435; C07D455/02
Attorney, Agent or Firm:
Kichi Toshio Kawa