QUINOLINE DERIVATIVES AS α4β7 INTEGRIN INHIBITORS

Japanese Patent JP2023016976

A

To provide a method for treating disease.SOLUTION: The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease. The present disclosure relates generally to novel compounds that have α4β7 integrin inhibitory action, prodrugs of compounds having α4β7 integrin inhibitory action, and methods of use and manufacture thereof.SELECTED DRAWING: None

Peter A. Bromgren
Taryn El. Campbell
Jayaraman Chandrasekhar
Christopher Tea. Clark
Julian A. Codelli
Kevin S. Curie
Jeffrey E. Klopp
Yasamin moi thistle
Nicole A. Nava
Reena Patel
Stephen Perrault
Jason Kay. Perry
Cassandra F. Sedillo
Natalie Seeger
Kirk El Stevens
Jennifer Ann Treiburg
Suet C. Yen
Zhongdong Zhao

JP2022195576A

February 02, 2023

December 07, 2022

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Gilead Sciences, Inc.

C07D215/14; A61K31/47; A61K31/4709; A61K31/4725; A61K31/496; A61K31/501; A61K31/506; A61K31/519; A61K31/5377; A61K31/5386; A61K31/541; A61K31/553; A61P1/04; A61P1/16; A61P3/10; A61P29/00; A61P37/06; A61P43/00; C07D215/22; C07D215/38; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/14; C07D407/12; C07D407/14; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D475/02; C07D487/04; C07D491/052; C07D491/06; C07D498/08; C07D498/10; C07D513/04

Shusaku Yamamoto
Morishita Natsuki

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