Title:
【発明の名称】キノキサリンジオン類
Document Type and Number:
Japanese Patent JPH11506123
Kind Code:
A
Abstract:
The invention provides compounds of the formula (I)or a pharmaceutically acceptable salt thereof,wherein R is a 5-membered ring heteroaryl group containing 3 or 4 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a ring carbon or nitrogen atom said group being optionally benzo-fused and optionally substituted, including in the benzo-fused portion, by 1 or 2 substituents each independently selected from C1-C4 alkyl, C2-C4 alkenyl, C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, C3-C7 cycloalkyloxy, -COOH, C1-C4 alkoxycarbonyl, -CONR3R4, -NR3R4, -S(O)p(C1-C4 alkyl), -SO2NR3R4, aryl, aryloxy, aryl(C1-C4)alkoxy, and het, said C1-C4alkyl being optionally substituted by C3-C7 cycloalkyl, halo, hydroxy, C1-C4 alkoxy, halo(C1C4)alkoxy, C3-C7 cycloalkyloxy, C3-C7 cycloalkyl (C1-C4) alkoxy, -COOH, C1-C4 alkoxycarbonyl, -CONR3R4, -NR3R4,-S(O)p(C1-C4 alkyl), -SO2(aryl), -SO2NR3R4 morpholino, aryl, aryloxy, aryl(C1-C4)alkoxy or het, and said C2-C4 alkenyl being optionally substituted by aryl; and R1 and R2 are each independently selected from H, fluoro, chloro, bromo, C1-C4 alkyl and halo(C1-C4)alkyl. The compounds are useful as NDMA receptor antagonists for treating acute neurodegenerative and chronic neurological disorders.
Inventors:
Bull, David John
Car, Christopher Lee
Frey, Michael Jonathan
Goce, Elizabeth Collette Louise
Charles Erick, Mowbray
Stove, Alan
Car, Christopher Lee
Frey, Michael Jonathan
Goce, Elizabeth Collette Louise
Charles Erick, Mowbray
Stove, Alan
Application Number:
JP53142997A
Publication Date:
June 02, 1999
Filing Date:
February 27, 1997
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K31/495; A61K31/498; A61K31/505; A61K31/506; A61K31/535; A61K31/5377; A61P25/00; A61P25/28; A61P43/00; C07D241/44; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D409/14; C07D413/14; C07D417/14; C07D521/00; (IPC1-7): C07D401/04; A61K31/495; A61K31/505; A61K31/535; C07D401/14; C07D403/04; C07D403/14; C07D409/14; C07D413/14; C07D417/14
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)