Title:
（Ｒ）−Ｎ−メチルナルトレキソン、その合成方法およびその医薬用途
Document Type and Number:
Japanese Patent JP5769693
Kind Code:
B2
Abstract:
This invention relates to pharmaceutical compositions containing R-MNTX, a chelating agent and a buffer. Such compositions my be useful for the treatment of an opioid incuced side effect in a patient, in particular constipation.
Inventors:
Harold Dee Doshan
Julio Perez
Julio Perez
Application Number:
JP2012278391A
Publication Date:
August 26, 2015
Filing Date:
December 20, 2012
Export Citation:
Assignee:
Progenics Pharmaceuticals, Incorporated
International Classes:
C07D489/08; A61K31/485; A61P1/00; A61P1/10; A61P1/12; A61P25/02
Foreign References:
| WO2004043964A1 |
Other References:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,1984年,V19 N4,P301-303
BIANCHETTI A,LIFE SCIENCES,英国,PERGAMON PRESS,1983年,V33 N.SUPPL.1,P415-418
BIANCHETTI A,LIFE SCIENCES,英国,PERGAMON PRESS,1983年,V33 N.SUPPL.1,P415-418
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai