Title:
RRP配列及びノックアウトマウスとその使用方法
Document Type and Number:
Japanese Patent JP2005537782
Kind Code:
A
Abstract:
RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
Inventors:
Francis-Lung, Helen
Friedman, Lori
Belvin, Masha
Plauman, Gregory, Dee.
Larson, Jeffrey, S.
Chen, Changyou
Robertston, Stephanie, A.
Riubin, Mario, N.
Sea, Wen
Chan, Jocelyn
Funke, roll, pee.
Lee, dunky
Kaozelman, Gunther
Tintorp, Hartmut
Zefnik, swing
Shawl, michael
Reardon, brian, john
Friedman, Lori
Belvin, Masha
Plauman, Gregory, Dee.
Larson, Jeffrey, S.
Chen, Changyou
Robertston, Stephanie, A.
Riubin, Mario, N.
Sea, Wen
Chan, Jocelyn
Funke, roll, pee.
Lee, dunky
Kaozelman, Gunther
Tintorp, Hartmut
Zefnik, swing
Shawl, michael
Reardon, brian, john
Application Number:
JP2003569678A
Publication Date:
December 15, 2005
Filing Date:
January 22, 2003
Export Citation:
Assignee:
Excelix Incorporated
International Classes:
A01K67/027; A61K31/7088; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C07K14/705; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12P21/08; C12Q1/02; C12Q1/37; C12Q1/42; C12Q1/48; C12Q1/527; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/573; G01N33/574; G01N33/68; A61K38/00; (IPC1-7): C12N15/09; A01K67/027; A61K31/7088; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08; C12Q1/02; C12Q1/37; C12Q1/68; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori