Title:
RSV遺伝子発現ワクチン
Document Type and Number:
Japanese Patent JP2005508927
Kind Code:
A
Abstract:
An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV results in significant induction of RSV-specific antibodies, nasal IgA antibodies, cytotoxic T lymphocytes, and IFN-gamma production in the lung and splenocytes. A single dose of GXV induces a drastic reduction of viral titers.
Inventors:
Mohaptra Siamese.
Kumar Mukesh
Fan Shaw
Leon Cam W.
Kumar Mukesh
Fan Shaw
Leon Cam W.
Application Number:
JP2003532089A
Publication Date:
April 07, 2005
Filing Date:
February 12, 2002
Export Citation:
Assignee:
University of South Florida
JOHNS HOPKINS UNIVERSITY
JOHNS HOPKINS UNIVERSITY
International Classes:
A61K9/62; A61K31/722; A61K39/12; A61K39/155; A61K48/00; A61P7/02; A61P11/00; A61P11/06; A61P17/02; A61P31/12; A61P37/00; A61P37/04; A61P43/00; C07K14/135; (IPC1-7): A61K39/12; A61K9/62; A61K31/722; A61K48/00; A61P7/02; A61P11/00; A61P11/06; A61P17/02; A61P31/12; A61P37/00; A61P37/04; A61P43/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi