Title:
RADIATION SENSITIZER CONTAINING PTERIN DERIVATIVE
Document Type and Number:
Japanese Patent JP2003292441
Kind Code:
A
Abstract:
To provide a radiation sensitizer.
The agent contains a pterin derivative of formula I, its cyclized compound or their salts. In formula I, R1 and R2 are each a 1-20C alkyl optionally substituted with one or more groups selected from OH, amino group, phosphoric acid group and sulfonic acid group, an acyl group of formula R3-CO (R3 is a 1-4C alkyl), an amino acid residue expressed by formula (a) or H; R4 is H or a 1-4C alkyl optionally substituted with one group selected from OH, carboxy, carbamoyl, mercapto, methylthio, amino, guanidino, imidazolyl, phenyl, hydroxyphenyl and indolyl; X is formyl or hydroxymethyl; A is a group of formula (Ia); and (n) is 0 or an integer of ≥1.
Inventors:
ARAI TOSHIYUKI
MAKINO KEISUKE
KONDO TAKASHI
OGAWA RYOHEI
MAKINO KEISUKE
KONDO TAKASHI
OGAWA RYOHEI
Application Number:
JP2002099052A
Publication Date:
October 15, 2003
Filing Date:
April 01, 2002
Export Citation:
Assignee:
CMIC CO LTD
International Classes:
C07D475/04; A61K31/519; A61P35/00; A61P43/00; (IPC1-7): A61K31/519; A61P35/00; A61P43/00; C07D475/04
Attorney, Agent or Firm:
Kenichi Morita
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