Title:
RADIATIVE METAL CHELATE
Document Type and Number:
Japanese Patent JPS63280088
Kind Code:
A
Abstract:
Radioactive metal ion chelates of N,N min -bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N min -diacetic acids, N,N min -bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N min -diacetic acids, and N,N min -bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N min -diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective agents for radiopharmaceutical imaging. Preferred contrast agents are radioactive metal ion such as technetium-99m and indium-111 ion chelates of N,N min -bis-(pyridoxal-5-phosphate)ethylenediamine-N,N min -diacetic acid, N,N min -bis-(pyridoxal- 5-phosphate)trans-1,2-cyclohexylenediamine-N,N min -diacetic acid, N,N min -bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N min -diacetic acid, and the soluble calcium salts thereof.
Inventors:
SUKOTSUTO EMU ROTSUKUEIJI
SUCHIIBUN SHII KII
SUCHIIBUN SHII KII
Application Number:
JP10993288A
Publication Date:
November 17, 1988
Filing Date:
May 07, 1988
Export Citation:
Assignee:
SALUTAR INC
International Classes:
A61B5/055; A61K51/04; C07B59/00; C07F1/00; C07F9/58; C07F13/00; A61K51/00; (IPC1-7): A61B10/00; A61K49/02; C07B59/00; C07F1/00; C07F9/58; C07F13/00
Attorney, Agent or Firm:
Heikichi Odashima
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