放射標識されたＭＯＥＭ型オリゴヌクレオチド及びその調製のための方法

Title:

放射標識されたＭＯＥＭ型オリゴヌクレオチド及びその調製のための方法

Document Type and Number:

Japanese Patent JP7366160

Kind Code:

B2

Abstract:

The invention comprises radiolabeled MOEM type oligonucleotide of the formula (I), (I) wherein n, X1, X2, the linker (1), the linker (2), Q* and the receptor targeting moiety are as defined (I) the description. The radiolabeled oligonucleotides of the formula (I) can be used for the determination of the biodistribution and pharmacokinetics of the oligonucleotide in the tissue or body fluid.

More Like This:

WO/2006/022629	METHODS OF IDENTIFYING RISK OF TYPE II DIABETES AND TREATMENTS THEREOF
WO/1996/010030	OLIGOMERS HAVING HETEROATOM-LINKED CONJUGATE GROUPS
WO/1997/015685	NUCLEIC ACID MOLECULES CAPABLE OF DISTINGUISHING THE ISOFORMS PrPc AND PrPSc OF PRION PROTEINS AND PROCESSES FOR THEIR PRODUCTION

Inventors:

edelman martin
Musser Thorsten

Application Number:

JP2021575227A

Publication Date:

October 20, 2023

Filing Date:

June 19, 2020

Export Citation:

Click for automatic bibliography generation Help

Assignee:

F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT

International Classes:

C07H21/02; A61K31/7125; A61K51/04; A61P43/00; C07H21/04; C12N15/11; C12Q1/68; C12Q1/6876

Foreign References:

US5847104

Other References:

REACTIVE AND FUNCTIONAL POLYMERS,2007年10月16日,Vol.67, No.11,pp.1373 - 1380,http://dx.doi.org/10.1016/j.reactfunctpolym.2007.07.036
Nucleoside, Nucleotide & Nucleic Acids,1999年,Vol.18, No2,pp.277-289
Proceedings of the National Academy of Sciences,1991年,Vol. 88,pp. 7595-7599

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto

Previous Patent: door guide device

Next Patent: Display modules, display panels, and display devices