Title:
RADIOSENSITIZATION USING TEXAPHYRIN
Document Type and Number:
Japanese Patent JP2004091495
Kind Code:
A
Abstract:
To obtain texaphyrin for radiosensitization.
A medicinal composition used for a radiosensitizer is prepared by using the texaphyrin. The texaphyrin is an aromatic 5 position (and heptacyclic) macrocycle (enlarged porphyrin) and, may be due to its inherent lipophilic property, shows larger biolocalization in non-neoplasm organs and non-atheroma plaque in neoplasm organ and atheroma each possible to be a malignant or benign tumor. The texaphyrin improves radiation damage and overcomes many defects of conventional radiosensitizers.
Inventors:
SESSLER JONATHAN L
HARRIMAN ANTHONY M
MILLER RICHARD A
MODY TARAK D
HEMMI GREGORY W
KRAAL VLADIMIR A
MAGDA DARREN
HARRIMAN ANTHONY M
MILLER RICHARD A
MODY TARAK D
HEMMI GREGORY W
KRAAL VLADIMIR A
MAGDA DARREN
Application Number:
JP2003377620A
Publication Date:
March 25, 2004
Filing Date:
November 06, 2003
Export Citation:
Assignee:
UNIV TEXAS
PHARMACYCLICS INC
PHARMACYCLICS INC
International Classes:
A61K31/40; A61K31/407; A61K41/00; A61K47/48; A61K49/00; A61K49/06; A61K49/08; A61K51/00; A61K51/04; A61L2/00; A61P35/02; A61P43/00; B01J31/16; B01J31/18; C07D487/22; C07H21/00; B01J31/06; (IPC1-7): A61K31/407; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto