RAF MODULATOR AND METHOD FOR USE THEREOF

Japanese Patent JP2010006840

A

To provide small-molecule compounds that specifically inhibit, regulate and/or modulate kinases, particularly Raf.

The invention relates to the compounds of formula I for modulating protein kinase enzymatic activity for modulating cellular activity such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. The compounds inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also aspects of the invention.

WO/2012/070069	A PROCESS FOR PREPARATION OF ALBENDAZOLE
WO/2011/019781	PROCESS FOR PREPARING 2-ARYLAMINO OR HETEROARYLAMINO SUBSTITUTED BENZIMIDAZOLE COMPOUNDS
JP2002338836	METAL CHELATE COLORING MATTER FOR INK JET RECORDING AND WATER-BASED INK JET RECORDING LIQUID OBTAINED USING THE SAME

ANAND NEEL KUMAR
BLAZEY CHARLES M
BOWLES OWEN JOSEPH
BUSSENIUS JOERG
COSTANZO SIMONA
CURTIS JEFFRY KIMO
DUBENKO LARISA
KENNEDY ABIGAIL R
DEFINA STEVEN CHARLES
KIM ANGIE I
MANALO JEAN-CLAIRE L
PETO CSABA J
RICE KENNETH D
TSANG TSZE H
JOSHI ANAGHA ABHIJIT

JP2009235794A

January 14, 2010

October 09, 2009

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EXELIXIS INC

C07D235/30; A61K31/416; A61K31/4184; A61K31/427; A61K31/4375; A61K31/4439; A61K31/454; A61K31/4965; A61K31/497; A61K31/498; A61K31/506; A61K31/538; A61P9/00; A61P35/00; A61P35/02; A61P43/00; C07D235/32; C07D401/14; C07D403/04; C07D403/06; C07D403/14; C07D405/04; C07D405/14; C07D409/12; C07D409/14; C07D413/04; C07D413/06; C07D413/14; C07D417/14; C07D471/04

WO2004103974A1

2004-12-02

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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