胃腸管(GIT)輸送受容体に結合するランダムペプチド、及び関連した方法

Japanese Patent JP4129298

B2

This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastro-intestinal tract, thus facilitating its absorption into the systemic system.

Albalets, Vernon, Elle.
Omahoney, Daniel, J.
Ramkin, Imelda, J.
Patterson, Kathleen, A.
Singleton, Judith
Berinka, Benjamin, A., Junior.
Carter, John, M.
Cagney, Gerald, M.

JP54964498A

August 06, 2008

May 15, 1998

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Sitegen Corporation
Elan Corporation PLC

C07K5/04; C12N15/09; A61K9/51; A61K38/00; A61K38/09; A61K38/28; A61K47/42; A61P5/48; A61P7/00; A61P7/06; A61P9/12; A61P19/10; A61P25/06; A61P35/00; A61P43/00; C07K1/04; C07K5/103; C07K5/107; C07K7/04; C07K14/00; C07K14/47; C07K14/705; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/68

Pharmaceutical Research, Vol.12, No.9 Suppl, pp.S-94 (Sep 1995)

Yusuke Hiraki
Ishii Teiji
Setuko Mayama

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